GEP19960467B - Method of producing derivatives of quinoline or their pharmaceutically acceptable esters or acid-additive salts - Google Patents
Method of producing derivatives of quinoline or their pharmaceutically acceptable esters or acid-additive saltsInfo
- Publication number
- GEP19960467B GEP19960467B GEAP19931276A GEAP1993001276A GEP19960467B GE P19960467 B GEP19960467 B GE P19960467B GE AP19931276 A GEAP19931276 A GE AP19931276A GE AP1993001276 A GEAP1993001276 A GE AP1993001276A GE P19960467 B GEP19960467 B GE P19960467B
- Authority
- GE
- Georgia
- Prior art keywords
- acid
- group
- methyl
- quinoline
- pharmaceutically acceptable
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 239000000654 additive Substances 0.000 title abstract 2
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24225785 | 1985-10-29 | ||
| JP28532385 | 1985-12-17 | ||
| JP3262786 | 1986-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP19960467B true GEP19960467B (en) | 1996-05-27 |
Family
ID=27287785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP19931276A GEP19960467B (en) | 1985-10-29 | 1993-07-29 | Method of producing derivatives of quinoline or their pharmaceutically acceptable esters or acid-additive salts |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4795751A (en]) |
| EP (2) | EP0375658B1 (en]) |
| JP (2) | JPS62277362A (en]) |
| KR (1) | KR910006806B1 (en]) |
| CN (1) | CN1009930B (en]) |
| AR (3) | AR242031A1 (en]) |
| AT (2) | ATE109472T1 (en]) |
| AU (1) | AU594983B2 (en]) |
| CA (1) | CA1340402C (en]) |
| DE (3) | DE3650018T2 (en]) |
| DK (2) | DK170593B1 (en]) |
| ES (2) | ES2029786T3 (en]) |
| FI (1) | FI87457C (en]) |
| GE (1) | GEP19960467B (en]) |
| GR (1) | GR3002475T3 (en]) |
| HU (1) | HU200452B (en]) |
| IL (1) | IL80404A (en]) |
| LU (2) | LU88596I2 (en]) |
| MY (1) | MY100574A (en]) |
| NL (2) | NL970020I2 (en]) |
| NO (1) | NO170726C (en]) |
| NZ (1) | NZ218089A (en]) |
| PH (1) | PH22862A (en]) |
| PT (1) | PT83643B (en]) |
| SU (2) | SU1635898A3 (en]) |
| YU (3) | YU46414B (en]) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977154A (en) * | 1985-12-12 | 1990-12-11 | Warner-Lambert Company | 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents |
| EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
| DE3711193A1 (de) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate |
| US5563138A (en) * | 1987-04-16 | 1996-10-08 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| US4780468A (en) * | 1987-08-07 | 1988-10-25 | Warner-Lambert Company | 8-trifluoromethyl quinolones as antibacterial agents |
| US5164392A (en) * | 1987-10-16 | 1992-11-17 | Dainippon Pharmaceutical Co., Ltd. | Quinoline derivatives and antibacterial agent containing them |
| IL88003A (en) * | 1987-10-16 | 1992-11-15 | Dainippon Pharmaceutical Co | Quinoline derivatives,their preparation and pharmaceutical compositions containing them |
| AU609974B2 (en) * | 1988-05-18 | 1991-05-09 | Warner-Lambert Company | Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids |
| JPH0674261B2 (ja) * | 1988-06-21 | 1994-09-21 | 塩野義製薬株式会社 | キノロンカルボン酸誘導体 |
| JP2709604B2 (ja) * | 1988-06-29 | 1998-02-04 | 大日本製薬株式会社 | マイコプラズマ汚染の防止または除去 |
| US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| FR2655545B1 (fr) | 1989-12-11 | 1994-06-10 | Rhone Poulenc Sante | Nouvelle application therapeutique des derives des fluoroquinolones. |
| DE4019023A1 (de) * | 1990-06-14 | 1991-12-19 | Bayer Ag | Verfahren zur herstellung von chinolincarbonsaeuren |
| JP2613139B2 (ja) * | 1990-07-19 | 1997-05-21 | エスエス製薬 株式会社 | キノロンカルボン酸誘導体 |
| US5342846A (en) * | 1990-12-05 | 1994-08-30 | Synphar Laboratories, Inc. | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents |
| FR2681863B1 (fr) * | 1991-09-27 | 1995-02-03 | Rhone Dpc Europ | Solution de sparfloxacine sa preparation et sel la constituant. |
| TW222272B (en]) * | 1992-05-26 | 1994-04-11 | Ss Seiyaku Kk | |
| WO1993025545A1 (en) * | 1992-06-09 | 1993-12-23 | Korea Research Institute Of Chemical Technology | Novel quinoline derivatives and processes for preparing the same |
| US5290794A (en) * | 1992-10-27 | 1994-03-01 | Warner Lambert Co. | Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms |
| US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| CN1038326C (zh) * | 1993-07-20 | 1998-05-13 | 爱斯制药株式会社 | 5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂 |
| US5532239A (en) * | 1993-08-02 | 1996-07-02 | Assistance Publique - Hopitaux De Paris | Therapeutic application of fluoroquinolone derivatives |
| IL143535A0 (en) | 1998-12-04 | 2002-04-21 | Influx Inc | Inhibitors of multidrug transporters |
| KR100768034B1 (ko) | 1999-03-17 | 2007-10-17 | 다이이찌 세이야꾸 가부시기가이샤 | 의약 조성물 |
| CN1091103C (zh) * | 1999-04-02 | 2002-09-18 | 中国科学院上海药物研究所 | 一类喹诺酮类化合物及它的制备和其用途 |
| US6957105B2 (en) * | 2002-03-26 | 2005-10-18 | Cardiac Pacemakers, Inc. | Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals |
| KR100519158B1 (ko) * | 2002-12-21 | 2005-10-06 | 주식회사유한양행 | 퀴놀론 카르복실레이트 유도체의 제조방법 |
| TWI289141B (en) * | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| US20070197548A1 (en) | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone compositions |
| US20070196398A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone fatty acid salt compositions |
| US7973022B2 (en) | 2006-02-17 | 2011-07-05 | Idexx Laboratories, Inc. | Fluoroquinolone carboxylic acid salt compositions |
| US20080139574A1 (en) | 2006-11-30 | 2008-06-12 | Cadila Healthcare Limited | Novel quinoline derivatives |
| CN111065385A (zh) | 2017-06-22 | 2020-04-24 | 希普拉有限公司 | 癌症的治疗方法 |
| CN112939860B (zh) * | 2019-11-11 | 2022-11-11 | 山东畜牧兽医职业学院 | 一种治疗耐药性革兰阴阳性菌的化合物及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753993A (en) * | 1971-05-17 | 1973-08-21 | Sterling Drug Inc | 1,4-dihydro-4-oxo-7-pyridyl-3-quinoline-carboxylic acid derivatives |
| DE3033157A1 (de) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| JPS58174367A (ja) | 1982-04-07 | 1983-10-13 | Tanabe Seiyaku Co Ltd | キノリン誘導体及びその製法 |
| DE3248506A1 (de) | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3248507A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel auf chinoloncarbonsaeure basis |
| DE3306771A1 (de) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| JPS60169475A (ja) * | 1984-02-14 | 1985-09-02 | Dai Ichi Seiyaku Co Ltd | キノリン誘導体 |
| DE3574380D1 (en) | 1984-02-17 | 1989-12-28 | Daiichi Seiyaku Co | 1,8-naphthyridine derivatives |
| US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
| ZA852369B (en) | 1984-04-26 | 1985-12-24 | Abbott Lab | Quinoline antibacterial compounds |
| DE3420798A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren |
| DE3420743A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| JPS6110574A (ja) * | 1984-06-25 | 1986-01-18 | Hokuriku Seiyaku Co Ltd | ６−フルオロ−１，４−ジヒドロ−４−オキソ−７−置換ピペラジニルキノリン−３−カルボン酸誘導体 |
| IE58742B1 (en) | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
| JPS6191183A (ja) * | 1984-10-11 | 1986-05-09 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| EP0181521A1 (en) * | 1984-10-19 | 1986-05-21 | Otsuka Pharmaceutical Co., Ltd. | Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds |
| US4636506A (en) * | 1984-12-06 | 1987-01-13 | Pfizer, Inc. | 7-heterocyclic-1,4-dihydroquinolones |
| DE3576335D1 (de) * | 1984-12-14 | 1990-04-12 | Daiichi Seiyaku Co | Chinolincarbonsaeure-derivate. |
| US4657913A (en) * | 1985-04-18 | 1987-04-14 | Warner-Lambert Company | Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents |
| JPS6259263A (ja) * | 1985-09-10 | 1987-03-14 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| US4668680A (en) * | 1985-12-12 | 1987-05-26 | Warner-Lambert Company | 5-amino-6,8-difluoroquinolones as antibacterial agents |
| US4977154A (en) * | 1985-12-12 | 1990-12-11 | Warner-Lambert Company | 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents |
| EP0230053A3 (en) * | 1986-01-17 | 1988-03-30 | American Cyanamid Company | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
| GB8612137D0 (en) * | 1986-05-19 | 1986-06-25 | Fujisawa Pharmaceutical Co | Quinolone compounds |
-
1986
- 1986-10-22 AU AU64277/86A patent/AU594983B2/en not_active Expired
- 1986-10-23 FI FI864299A patent/FI87457C/fi not_active IP Right Cessation
- 1986-10-23 NO NO864247A patent/NO170726C/no not_active IP Right Cessation
- 1986-10-23 AT AT90101210T patent/ATE109472T1/de active
- 1986-10-23 ES ES198686114748T patent/ES2029786T3/es not_active Expired - Lifetime
- 1986-10-23 DE DE3650018T patent/DE3650018T2/de not_active Expired - Lifetime
- 1986-10-23 EP EP90101210A patent/EP0375658B1/en not_active Expired - Lifetime
- 1986-10-23 DE DE2000175028 patent/DE10075028I2/de active Active
- 1986-10-23 LU LU88596C patent/LU88596I2/fr unknown
- 1986-10-23 AT AT86114748T patent/ATE66210T1/de not_active IP Right Cessation
- 1986-10-23 ES ES90101210T patent/ES2057197T3/es not_active Expired - Lifetime
- 1986-10-23 EP EP86114748A patent/EP0221463B1/en not_active Expired - Lifetime
- 1986-10-23 IL IL80404A patent/IL80404A/xx not_active IP Right Cessation
- 1986-10-23 DE DE8686114748T patent/DE3680859D1/de not_active Expired - Lifetime
- 1986-10-24 HU HU864479A patent/HU200452B/hu unknown
- 1986-10-28 NZ NZ218089A patent/NZ218089A/xx unknown
- 1986-10-28 US US06/928,297 patent/US4795751A/en not_active Expired - Lifetime
- 1986-10-28 DK DK514586A patent/DK170593B1/da not_active IP Right Cessation
- 1986-10-28 CA CA000521561A patent/CA1340402C/en not_active Expired - Lifetime
- 1986-10-28 MY MYPI86000045A patent/MY100574A/en unknown
- 1986-10-28 JP JP61257175A patent/JPS62277362A/ja active Granted
- 1986-10-29 AR AR86305742A patent/AR242031A1/es active
- 1986-10-29 YU YU183586A patent/YU46414B/sh unknown
- 1986-10-29 KR KR1019860009083A patent/KR910006806B1/ko not_active Expired
- 1986-10-29 PT PT83643A patent/PT83643B/pt unknown
- 1986-10-29 PH PH34426A patent/PH22862A/en unknown
- 1986-10-29 CN CN86107491A patent/CN1009930B/zh not_active Expired
-
1987
- 1987-10-27 SU SU874203544A patent/SU1635898A3/ru active
- 1987-10-27 SU SU874203548A patent/SU1598873A3/ru active
-
1990
- 1990-11-19 AR AR90318409A patent/AR243178A1/es active
- 1990-11-19 AR AR90318410A patent/AR243520A1/es active
-
1991
- 1991-08-08 YU YU137191A patent/YU137191A/sh unknown
- 1991-08-08 YU YU137291A patent/YU137291A/sh unknown
- 1991-08-16 GR GR91401047T patent/GR3002475T3/el unknown
- 1991-12-26 JP JP35979491A patent/JPH0714918B2/ja not_active Expired - Lifetime
-
1992
- 1992-02-28 DK DK025992A patent/DK170774B1/da not_active IP Right Cessation
-
1993
- 1993-07-29 GE GEAP19931276A patent/GEP19960467B/en unknown
-
1997
- 1997-05-30 NL NL970020C patent/NL970020I2/nl unknown
-
2000
- 2000-08-08 NL NL300014C patent/NL300014I2/nl unknown
- 2000-08-09 LU LU90621C patent/LU90621I2/fr unknown
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